Panax notoginseng (Burk) F.H. Chen, a valuable traditional medicinal plant belongs to the Araliaceae family, is extensively employed in several Asian countries for centuries. The biological activities of Panax notoginseng saponins (PNS), which are the main active constituents, have been attracting growing attention due to their diverse health-promoting effects. In this review, an attempt has been made to provide up-to-date information about the progress in the analytical methods and the biological activities of PNS.
Analytical Methods:
The quality and therapeutic efficacy of herbal medicines are directly linked with their qualitative and quantitative analyses. Various approaches have been applied in isolating and analyzing PNS, including high-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC), mass spectrometry (MS), nuclear magnetic resonance (NMR), and other advanced techniques. These methods allow for the accurate identification and quantitative analysis of the major saponin components.
Biological Activities:
Numerous in vitro and in vivo studies have demonstrated that PNS exhibits a wide range of biological activities. A few of these include being an anti-inflammatory, anti-oxidant, and anti-cancer agent. It can also enhance immunity, have hepatoprotective effects, improve cardiovascular health, promote wound healing, and have neuroprotective effects.
Recent Trends:
Recently, research on PNS has focused on further exploration of its therapeutic benefits and mechanisms of action, as well as improvement in the extraction and analytical techniques. The use of nanotechnology in the delivery of PNS to enhance its bioavailability and therapeutic effectiveness is a significant recent trend.
In conclusion, PNS have immense potential for the development of novel therapeutic agents. Future research should be aimed at exploiting this potential, improving extraction and analytical methods, and enhancing the bioavailability of PNS to ensure effective delivery in the body. |
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