Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR

发表于 2026-7-27 08:55:24

期刊：Journal of Medicinal Chemistry

文献作者：Hubert Josien; Anilkumar G. Nair; Fa-Xiang Ding; Yan Guo; Yi-Heng Chen; Ashwin U. Rao; Jian Liu; Ling Tong; Zhongxiang Sun; Michael M.-C. Lo; Thomas J. Tucker; Mark W. Embrey; Aurash Shahripour; Chengwei Wu; Elisabetta Bianchi; Danila Branca; Jeffrey T. Kuethe; Joshua Lee; David A. Thaisrivongs; Paul G. Bulger; Xiaohong Zhu; Sookhee N. Ha; Jennifer M. Johnston; Daniel J. Klein; Peter Orth; Mee Ra Hong; Alexei V. Buevich; Qi Gao; Hratch J. Zokian; Kenneth A. Koeplinger; Rodger W. Tracy; Michael J. Hafey; Nicole Buist; Tjerk Bueters; Candice Alleyne; Alan Bass; Louis-Charles Campeau; Douglas G. Johns; Robert M. Garbaccio; Petr Vachal; Abbas Walji; Harold B. Wood

出版日期：2026-6-11

DOI号：10.1021/acs.jmedchem.6c00463

下载链接：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6c00463

文献链接：https://doi.org/10.1021/acs.jmedchem.6c00463

当前文献来源于 American Chemical Society (ACS)。

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[ACS] Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR

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