Antibody-Drug Conjugates of NLRP3 Agonists: How Overcoming Lysosomal Accumulation Necessitated Noncanonical Linker Attachments

发表于 2026-7-31 09:22:24

期刊：Journal of Medicinal Chemistry

文献作者：Paul S. Riehl; Meng Yao Zhang; Payal Dhar; Zhiying Wang; Jie Pan; Kathleen Mansfield; Walter L. Johnson; Qian Zhang; Yvonne Li; Ryan D’Souza; Jun Zhang; Jonathan Olsen; Madhura Deshpande; Srikanth Kotapati; Scott A. Hollingsworth; Isha Verma; Yi-xin Li; Yang Su; Qinqin Cheng; Sayumi Yamazoe; Luca Micci; Miranda Broz; James Janc; Eugene P. Chekler; Julian C. Lo

出版日期：2025-5-8

DOI号：10.1021/acs.jmedchem.5c00596

下载链接：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c00596

文献链接：https://doi.org/10.1021/acs.jmedchem.5c00596

当前文献来源于 American Chemical Society (ACS)。

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[ACS] Antibody-Drug Conjugates of NLRP3 Agonists: How Overcoming Lysosomal Accumulation Necessitated Noncanonical Linker Attachments

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