A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis

发表于 2026-8-30 18:26:46

期刊：Science Translational Medicine

文献作者：Shawn C. Chafe; Kui Zhai; Nikoo Aghaei; Petar Miletic; Zhi Huang; Kevin R. Brown; Daniel Mobilio; Daniel Young; Yujin Suk; Shan Grewal; Dillon McKenna; Zahra Alizada; Agata M. Kieliszek; Fred C. Lam; Laura Escudero; Qian Huang; Ariana Huebner; Jack Lu; Patrick Ang; Alisha Anand; Stefan Custers; Erika Apel; Sarah Slassi; Benjamin Brakel; Jongmyung Kim; James K. C. Liu; Blessing Iquo Bassey-Archibong; Rober Abdo; Yaron Shargall; Jian-Qiang Lu; Jean-Claude Cutz; Qi Zhang; Shawn Shun-Cheng Li; Chitra Venugopal; Robert E. Hynds; Antoine Dufour; Jason Moffat; Charles Swanton; Shideng Bao; Sheila K. Singh

出版日期：2025-7-2

DOI号：10.1126/scitranslmed.adu2459

下载链接：https://www.science.org/doi/pdf/10.1126/scitranslmed.adu2459

文献链接：https://doi.org/10.1126/scitranslmed.adu2459

当前文献来源于 American Association for the Advancement of Science (AAAS)。

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[AAAS] A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis

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