Discovery ofBMS-986449: A Potent, Selective Degraderof the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to TargetRegulatory T Cells in Solid Tumors

发表于 2026-9-7 17:08:00

期刊：Journal of Medicinal Chemistry

文献作者：Emily C. Cherney; Satheesh K. Nair; Suresh Babu Viswa Krishna Penmetsa; Bharat Shimpukade; Audris Huang; Donna Bilder; Andrew P. Degnan; Godwin K. Kumi; Liping Zhang; Ashok V. Purandare; Fukang Yang; Guo Li; Weifang Shan; Yan Chen; Shuqun Lin; Peter Park; Dharmpal S. Dodd; Durgarao Kantheti; Sivaramakrishna Padamata; Raju K. V. L. P. Manepalli; Naga Malleswara Reddy Sirigireddy; Malappa Malappa; T. G. Murali Dhar; Cullen L. Cavallaro; Ling Li; Martins S. Oderinde; Daniel Smith; Joseph M Pawluczyk; James Kempson; Muthalagu Vetrichelvan; Anuradha Gupta; Arvind Mathur; Richard Rampulla; Carolyn A. Weigelt; Sirish Kaushik Lakkaraju; Purnima Khandelwal; Madhu Katepalli; Thaiya Nachiar K. Lenin; Stephan Riedmaier; Keith DiPetrillo; Kimberly A. Foster; Mohan Krishna Rayeni; Vikas Choure; Torsa Das; Steven Levine; Monica Kwok; Mary Ellen Cvijic; Xin Li; Hua Fang; Debarati Mazumder Tagore; Madhu Sudhan Ravindran; Sheetal R. Gujaran; Anupama Natarajan; Jinyi Zhu; Barbra Pagarigan; Pavan Srinivas; Ari Salinger; Ashok R. Dongre; Harris Bell-Temin; Helen Pham; Pathik Rakesh Desai; Olivia Calder; Lihong Shi; Sixuan Guo; Godrej Khambatta; Pallavur Sivakumar; Nadia Ladygina; Rama Krishna Narla; Gopal Dhar; Aravind Anandam; Vidhi Khanna; Shailesh Dudhgaonkar; Jinqi Liu; Michael J. Barnes; Robert Borzilleri; Louis J. Lombardo; Gregory Vite; John T. Hunt; Aaron Balog

出版日期：--

DOI号：10.1021/acs.jmedchem.6c01271

下载链接：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6c01271

文献链接：https://doi.org/10.1021/acs.jmedchem.6c01271

当前文献来源于 American Chemical Society (ACS)。

备注信息：

发表于 2026-9-7 17:08:01

: 当前求助已完成，请重新发起求助。
已完结状态的附件将会在24小时内删除。

发表于 2026-9-7 21:48:45

: 当前求助已完成，请重新发起求助。
已完结状态的附件将会在24小时内删除。

[ACS] Discovery ofBMS-986449: A Potent, Selective Degraderof the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to TargetRegulatory T Cells in Solid Tumors

已采纳

同分类求助

最新回复

站点公告

今日热心研友

（热心研友QQ群）

[ACS] Discovery ofBMS-986449: A Potent, Selective Degraderof the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to TargetRegulatory T Cells in Solid Tumors 一键复制