Rosaceae) attenuates carbon tetrachloride-induced hepatic fibrosis in vivo via modulating oxidative stress and inflammation (Hamza et al, 2020). TCMs are derived from animals, plants and mineral agents with certain pharmacological activities, and herbal medicines and their formulas are dominant (Shan et al, 2019). TCMs have attracted much attention due to their unique advantages, such as wide sources, lower prices, few side effects, etc. Previous evidence suggests that many agents derived from TCMs could be beneficial for the treatment or prevention of HF (Shan et al, 2019). So far, more than 76 natural compounds with anti-hepatic fibrosis activities have been isolated and identified from TCMs, including alkaloids, flavones, quinones, terpenoids, saponins, phenylpropanoids, and polysaccharides, etc. The anti-hepatic fibrosis effects of these compounds include hepatoprotection, inhibition of hepatic stellate cells (HSC) activation, regulation of extracellular matrix (ECM) synthesis & secretion, regulation of autophagy, and antioxidant & anti-inflammation, etc. (Figure 2).
In the present review, we summarized the potential anti-hepatic fibrosis components from TCMs and their possible molecular mechanisms, which would be of great significance to develop novel drugs against hepatic fibrosis.
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